CalDAG-GEFI and platelet activation
نویسندگان
چکیده
منابع مشابه
PLATELETS AND THROMBOPOIESIS CalDAG-GEFI is at the nexus of calcium-dependent platelet activation
The importance of the second messengers calcium (Ca2 ) and diacylglycerol (DAG) in platelet signal transduction was established more than 30 years ago. Whereas protein kinase C (PKC) family members were discovered as the targets of DAG, little is known about the molecular identity of the main Ca2 sensor(s). We here identify Ca2 and DAG-regulated guanine nucleotide exchange factor I (CalDAG-GEFI...
متن کاملCalDAG-GEFI is at the nexus of calcium-dependent platelet activation.
The importance of the second messengers calcium (Ca(2+)) and diacylglycerol (DAG) in platelet signal transduction was established more than 30 years ago. Whereas protein kinase C (PKC) family members were discovered as the targets of DAG, little is known about the molecular identity of the main Ca(2+) sensor(s). We here identify Ca(2+) and DAG-regulated guanine nucleotide exchange factor I (Cal...
متن کاملHuman CalDAG-GEFI gene (RASGRP2) mutation affects platelet function and causes severe bleeding
The nature of an inherited platelet disorder was investigated in three siblings affected by severe bleeding. Using whole-exome sequencing, we identified the culprit mutation (cG742T) in the RAS guanyl-releasing protein-2 (RASGRP2) gene coding for calcium- and DAG-regulated guanine exchange factor-1 (CalDAG-GEFI). Platelets from individuals carrying the mutation present a reduced ability to acti...
متن کاملMice Expressing Low Levels of CalDAG-GEFI Exhibit Markedly Impaired Platelet Activation With Minor Impact on Hemostasis.
OBJECTIVE The tight regulation of platelet adhesiveness, mediated by the αIIbβ3 integrin, is critical for hemostasis and prevention of thrombosis. We recently demonstrated that integrin affinity in platelets is controlled by the guanine nucleotide exchange factor, CalDAG-GEFI (CD-GEFI), and its target, RAP1. In this study, we investigated whether low-level expression of CD-GEFI leads to protect...
متن کاملCalDAG-GEFI Deficiency Reduces Atherosclerotic Lesion Development in Mice.
OBJECTIVE Platelets are important for the development and progression of atherosclerotic lesions. However, relatively little is known about the contribution of platelet signaling to this pathological process. Our recent work identified 2 independent, yet synergistic, signaling pathways that lead to the activation of the small GTPase Rap1; one mediated by the guanine nucleotide exchange factor, ...
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ژورنال
عنوان ژورنال: Platelets
سال: 2010
ISSN: 0953-7104,1369-1635
DOI: 10.3109/09537101003639931